Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy
نویسندگان
چکیده
منابع مشابه
Serrated lesions and hyperplastic (serrated) polyposis relationship with colorectal cancer: classification and surveillance recommendations.
Colorectal carcinoma (CRC) is the third most commonly morphology, and, moreover, some of them turned out to diagnosed cancer and the third leading cause of cancer death in both sexes in the United States. However, in Central and Eastern Europe, CRC has recently become the second most common cancer, after lung cancer in men and breast cancer in women. In the past decade, there has been unprecede...
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...................................................................................................................... 9 REVIEW OF THE LITERATURE .............................................................................. 11 1. GENES AND CANCER...........................................................................................................................11 1.1 Oncogenes..............
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PURPOSE Recently, activating mutations of the epidermal growth factor receptor (EGFR) gene were discovered in non-small cell lung cancers sensitive to gefitinib (ZD1839, an EGFR tyrosine kinase inhibitor) but not in gefitinib-resistant cancers. Abnormalities of EGFR and related pathways may have an effect on responsiveness of advanced colorectal cancer to combination chemotherapy with gefitinib...
متن کاملModeling the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA).
Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of co...
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Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC pa...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2016
ISSN: 1007-9327
DOI: 10.3748/wjg.v22.i13.3516